See USP Controlled Room Temperature. If you have any questions about Glucotrol XL extended-release tablets, please talk with your doctor, pharmacist, or other health care provider. Seek medical attention if you think any of your asthma medications are not working as well as usual. An increased need for medication could be an early sign of a serious asthma attack. If you use a peak flow meter at home, call your doctor if your numbers are lower than normal. purchase generic cefdinir store
Do not miss any doses. Safety and efficacy have not been established in patients younger than 18 years. Cholestatic and hepatocellular forms of liver injury accompanied by jaundice have been reported rarely in association with glipizide; Glipizide and Metformin HCl Tablets should be discontinued if this occurs. The most common side effects of Glucotrol XL include: dizziness, diarrhea, nervousness, tremor, and gas. The metabolic and excretory patterns are similar with the two routes of administration, indicating that first-pass metabolism is not significant. Glucotrol does not accumulate in plasma on repeated oral administration. Total absorption and disposition of an oral dose was unaffected by food in normal volunteers, but absorption was delayed by about 40 minutes. Thus, Glucotrol was more effective when administered about 30 minutes before, rather than with, a test meal in diabetic patients.
GLUCOTROL included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. When this medication is used for a long time, it may not work as well. Talk with your doctor if this medication stops working well.
Tell your doctor or dentist that you take Glucotrol XL extended-release tablets before you receive any medical or dental care, emergency care, or surgery. It may be harder to control your blood sugar when your body is stressed such as due to fever, infection, injury, or surgery. Consult your doctor because this may require a change in your treatment plan, medications, or blood sugar testing. Are breastfeeding or plan to breastfeed. It is not known if Glucotrol XL passes into your breast milk. You and your healthcare provider should decide if you will take Glucotrol XL or breastfeed. You should not do both.
The effectiveness of any oral hypoglycemic drug, including Glipizide, in lowering blood glucose to a desired level decreases in many patients over a period of time, which may be due to progression of the severity of the diabetes or to diminished responsiveness to the drug. This phenomenon is known as secondary failure, to distinguish it from primary failure in which the drug is ineffective in an individual patient when first given. Do not use this medication if you are allergic to glipizide, or if you are in a state of diabetic ketoacidosis. Call your doctor for treatment with insulin. Blood and urine glucose should be monitored periodically. Measurement of glycosylated hemoglobin may be useful. Read the Patient Information Leaflet if available from your before you start taking and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Certain drugs tend to produce hyperglycemia and may lead to loss of control. These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid. When such drugs are administered to a patient receiving Glucotrol, the patient should be closely observed for loss of control. When such drugs are withdrawn from a patient receiving Glucotrol, the patient should be observed closely for hypoglycemia. Re-evaluate eGFR 48 hours after the imaging procedure, and restart Glipizide and Metformin HCl Tablets if renal function is stable. Do not use Serevent Diskus to treat an asthma attack that has already begun. It will not work fast enough. Use only a fast-acting inhalation medication. Always keep a source of sugar available in case you have symptoms of low blood sugar. Sugar sources include orange juice, glucose gel, candy, or milk. If you have severe hypoglycemia and cannot eat or drink, use an injection of glucagon. Your doctor can give you a prescription for a glucagon emergency injection kit and tell you how to give the injection. If you also take colesevelam, take Glucotrol XL extended-release tablets at least 4 hours before your dose of colesevelam. Check with your doctor if you have questions. If you think you may be pregnant, contact your doctor. It is not known if this medicine is found in breast milk. As with other sulfonylurea-class hypoglycemics, many stable non-insulin-dependent diabetic patients receiving insulin may be safely placed on Glucotrol. When transferring patients from insulin to Glucotrol, the following general guidelines should be considered: For patients whose daily insulin requirement is 20 units or less, insulin may be discontinued and Glucotrol therapy may begin at usual dosages. Several days should elapse between Glucotrol titration steps. For patients whose daily insulin requirement is greater than 20 units, the insulin dose should be reduced by 50% and Glucotrol therapy may begin at usual dosages. Subsequent reductions in insulin dosage should depend on individual patient response. Several days should elapse between Glucotrol titration steps. It may increase the risk of death from heart disease. Talk with your doctor about the benefits and risks of this or other therapies to treat your condition. Some forms of glipizide are made with a shell that is not absorbed or melted in the body. Part of the tablet shell may appear in your stool. This is a normal side effect and will not make the medication less effective. In a placebo-controlled, crossover study in normal volunteers, glipizide had no antidiuretic activity and, in fact, led to a slight increase in free water clearance. Doses can be adjusted with caution taking into account the degree of hepatic, renal, or cardiac function, and the concomitant disease or other drug therapy.
NaOH; it is freely soluble in dimethylformamide. Each tablet, for oral administration, contains 5 mg or 10 mg glipizide. If you don't have these reliable forms of glucose, rapidly raise your by eating a quick source of sugar such as table sugar, honey, or candy, or drink fruit juice or non-diet soda. Tell your doctor right away about the reaction and the use of this product. Glipizide Tablets due to potential overlapping of drug effect. This medication may make you more sensitive to the sun. Limit your time in the sun. Avoid tanning booths and sunlamps. Use and wear protective clothing when outdoors. Rees LH. Chlorpropamide alcohol flush and circulating met-enkephalin: a positive link. Cases of and the syndrome of inappropriate SIADH secretion have been reported with this and other sulfonylureas. This information should not be used to decide whether or not to take Glucotrol XL extended-release tablets or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Glucotrol XL extended-release tablets. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Glucotrol XL extended-release tablets. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Glucotrol XL extended-release tablets. This information should not be used to decide whether or not to take Glucotrol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Glucotrol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Glucotrol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using Glucotrol. Dizziness, drowsiness, and headache have each been reported in about 1 in 50 patients treated with glipizide. They are usually transient and seldom require discontinuance of therapy. XL is co-administered with fluconazole. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. Concomitant use of these drugs with Glipizide and Metformin HCl Tablets may increase the risk for lactic acidosis. Consider more frequent monitoring of these patients. If metformin-associated lactic acidosis is suspected, general supportive measures should be instituted promptly in a hospital setting, along with immediate discontinuation of Glipizide and Metformin HCl Tablets. Some patients fail to respond initially, or gradually lose their responsiveness to sulfonylurea drugs, including Glipizide. Alternatively, Glipizide may be effective in some patients who have not responded or have ceased to respond to other sulfonylureas. For patients with daily insulin doses greater than 20 units: Insulin dose should be reduced by 50% and glipizide therapy may begin at usual dosages. Safety and effectiveness in children have not been established. trazodone
Muscles are also the primary site of insulin resistant. Ask your doctor or pharmacist about other ways to decrease such as lying down for 1 to 2 hours with as little head movement as possible. According to a review of past studies on these herbs published in the April issue of the journal Diabetes Care, all of them have shown promise for helping to regulate blood sugar levels. Nevertheless, none of the evidence counts as solid proof. The studies reviewed had shortcomings that leave the results open to question. In short, more research is needed. Periodic fasting blood glucose FBG and HbA 1c measurements should be performed to monitor therapeutic response. Although only 1 drug in the sulfonylurea class tolbutamide was included in this study, it is prudent from a safety standpoint to consider that this warning may also apply to other hypoglycemic drugs in this class, in view of their close similarities in mode of action and chemical structure. Keep all away from children and pets. The hypoglycemic action of sulfonylureas may be potentiated by certain drugs, including nonsteroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein-bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, and beta adrenergic blocking agents. When such drugs are administered to a patient receiving Glipizide and Metformin HCl Tablets, the patient should be observed closely for hypoglycemia. When such drugs are withdrawn from a patient receiving Glipizide and Metformin HCl Tablets, the patient should be observed closely for loss of blood glucose control. In vitro binding studies with human serum proteins indicate that glipizide binds differently than tolbutamide and does not interact with salicylate or dicumarol. However, caution must be exercised in extrapolating these findings to the clinical situation and in the use of Glipizide and Metformin HCl Tablets with these drugs. Despite controversy regarding the interpretation of these results, the findings of the UGDP study provide an adequate basis for this warning. The patient should be informed of the potential risks and benefits of glipizide and of alternative modes of therapy. Patients should be closely monitored for a minimum of 24 to 48 hours since hypoglycemia may recur after apparent clinical recovery. Clearance of glipizide from plasma would be prolonged in persons with liver disease. Because of the extensive protein binding of glipizide, dialysis is unlikely to be of benefit. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Hemodialysis has often resulted in reversal of symptoms and recovery. This medication may cause withdrawal reactions, especially if it has been used regularly for a long time or in high doses. trazodone order shop uk trazodone
Overdosage of sulfonylureas, including Glipizide, can produce hypoglycemia. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. There have been no clinical studies establishing conclusive evidence of risk reduction with GLUCOTROL or any other anti-diabetic drug. You may notice the tablet shell in your stool with some brands of Glucotrol XL extended-release tablets. This is normal and not a cause for concern. Your diabetic medicine may also make you intolerant to alcohol. Symptoms of alcohol intolerance include flushing, throbbing in the head and neck, irregular heart beat, rapid heart beat, low blood pressure, sweating, nausea, and vomiting. This can happen if you are sick with a fever, vomiting, or diarrhea. Dehydration can also happen when you sweat a lot with activity or exercise and do not drink enough fluids. Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure convulsions. What should I avoid while taking Glucotrol XL glipizide? Do not increase your dose, take the medication more frequently, or take it for a longer time than prescribed. Properly stop the medication when so directed. There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with glipizide or any other anti-diabetic drug. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. For patients whose daily insulin requirement is greater than 20 units, the insulin dose should be reduced by 50% and Glipizide therapy may begin at usual dosages. Contact your doctor or health care provider right away if any of these apply to you. betapace kit online
Some patients fail to respond initially, or gradually lose their responsiveness to sulfonylurea drugs, including glipizide. Alternatively, glipizide may be effective in some patients who have not responded or have ceased to respond to other sulfonylureas. Consult your doctor or pharmacist about the safe use of alcohol. When adding other blood-glucose-lowering agents to glipizide extended release, the agent should be initiated at the lowest recommended dose. Observe for hypoglycemia. Cmax, -4% and 0%, respectively. Therefore, Glipizide and Metformin HCl Tablets should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glipizide. Do not start, stop, or change the dosage of any medicine before checking with them first. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with Glipizide and Metformin HCl Tablets or any other antidiabetic drug. This may not be a complete list of all interactions that may occur. Ask your health care provider if Glucotrol XL extended-release tablets may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine. In addition, each tablet contains the following inactive ingredients: Sodium Starch Glycolate, Corn Starch, Povidone, Magnesium Stearate, Colloidal Silicon Dioxide, Hypromellose, Talc, Titanium Dioxide, Polyethylene Glycol 6000, Propylene Glycol and Iron Oxide Red. The tablets are film coated, which provides color differentiation.
Glucotrol has been demonstrated in a placebo controlled crossover study in healthy volunteers. Glucotrol due to potential overlapping of drug effect. Known hypersensitivity to glipizide or any of the product's ingredients. The absolute bioavailability of glipizide was 100% after single oral doses in patients with type 2 diabetes mellitus. Beginning 2 to 3 hours after administration of Glucotrol XL, plasma drug concentrations gradually rise reaching maximum concentrations within 6 to 12 hours after dosing. With subsequent once daily dosing of Glucotrol XL, plasma glipizide concentrations are maintained throughout the 24 hour dosing interval with less peak to trough fluctuation than that observed with twice daily dosing of immediate release glipizide. Close monitoring should continue until the physician is assured that the patient is out of danger. order cheapest permethrin shop australia
There were no overall differences in effectiveness or safety between younger and older patients, but greater sensitivity of some individuals cannot be ruled out. Elderly patients are particularly susceptible to the hypoglycemic action of anti-diabetic agents. Hypoglycemia may be difficult to recognize in these patients. Therefore, dosing should be conservative to avoid hypoglycemia. Talk to your pharmacist if you have questions about this information. The apparent volume of distribution of Glucotrol after intravenous administration was 11 liters, indicative of localization within the extracellular fluid compartment. In mice, no Glucotrol or metabolites were detectable autoradiographically in the brain or spinal cord of males or females, nor in the fetuses of pregnant females. In another study, however, very small amounts of radioactivity were detected in the fetuses of rats given labelled drug. Also watch for signs of blood sugar that is too high hyperglycemia. These symptoms include increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, and weight loss. Your blood sugar will need to be checked often, and you may need to adjust your glipizide dose. Glipizide is an oral antihyperglycemic drug of the sulfonylurea class. The body needs this mineral to regulate blood sugar, but the ADA says taking a chromium supplement wouldn't do most people with diabetes any good. Research shows that chromium supplements can help those who have too little chromium, but most don't have a deficiency. Known hypersensitivity to the drug. Do not share this medication with others. onneto.info aciphex
Patients should be counseled against excessive alcohol intake, either acute or chronic, while receiving Glipizide and Metformin HCl Tablets. See printed below. FDA pregnancy category C. It is not known whether glipizide will harm an unborn baby. Similar diabetes medications have caused severe hypoglycemia in newborn babies whose mothers had used the medication near the time of delivery. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Glucotrol XL tablets were bioequivalent to one 10-mg Glucotrol XL tablet. The cause of the interaction is not known. When these two medicines are taken together, your body may produce more insulin than expected. Your body may not respond properly to low blood sugar levels. There is no fixed dosage regimen for the management of diabetes mellitus with Glipizide or any other hypoglycemic agent. Nausea, vomiting, loss of appetite, diarrhea, constipation, upset stomach, headache, and weight gain may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Store at room temperature away from light and moisture. Different brands of this have different storage needs. For patients with daily insulin doses of 20 units or less: Discontinue insulin and begin glipizide at usual dosages. WARNING: A small number of people who have taken metformin hydrochloride have developed a serious condition called lactic acidosis. Tell your doctor if you have severe kidney problems. Other brands listed are the trademarks of their respective owners. Therefore, Glucotrol should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glipizide. Do NOT take more than the recommended dose without checking with your doctor. It has been shown that glipizide therapy was effective in controlling blood sugar without deleterious changes in the plasma lipoprotein profiles of patients treated for NIDDM. National Center for NCCAM. Take the missed dose 30 minutes before your next meal, then return to your regular schedule. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. isotrexin
GLUCOTROL XL affects you. Glipizide primarily lowers blood glucose by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. Sulfonylureas bind to the sulfonylurea receptor in the pancreatic beta-cell plasma membrane, leading to closure of the ATP-sensitive potassium channel, thereby stimulating the release of insulin. The pattern of laboratory test abnormalities observed with Glipizide was similar to that for other sulfonylureas. Occasional mild to moderate elevations of SGOT, LDH, alkaline phosphatase, BUN, and creatinine were noted. One case of jaundice was reported. The relationship of these abnormalities to Glipizide is uncertain, and they have rarely been associated with clinical symptoms. At least several days should elapse between titration steps. If response to a single dose is not satisfactory, dividing that dose may prove effective. The maximum recommended once daily dose is 15 mg. Doses above 15 mg should ordinarily be divided and given before meals of adequate caloric content. Hypoglycemia was not reported for any placebo patients. When I was first diagnosed I was put on Metformin and Glipizide. Anyway, when my BG's started coming down I started having lows. When colesevelam is coadministered with Glipizide ER, maximum plasma concentration and total exposure to Glipizide is reduced. Therefore, Glipizide should be administered at least 4 hours prior to colesevelam. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. Educate patients to recognize and manage hypoglycemia. What are the side effects of salmeterol? It has gotten worse over the past year. The risks of lactic acidosis associated with metformin therapy, its symptoms, and conditions that predispose to its development, as noted in the and sections, should be explained to patients. Patients should be advised to discontinue Glipizide and Metformin HCl Tablets immediately and promptly notify their health practitioner if unexplained hyperventilation, myalgia, malaise, unusual somnolence, or other nonspecific symptoms occur. Once a patient is stabilized on any dose level of Glipizide and Metformin HCl Tablets, gastrointestinal symptoms, which are common during initiation of metformin therapy, are unlikely to be drug related. Later occurrence of gastrointestinal symptoms could be due to lactic acidosis or other serious disease. Dornhorst A, Ouyang A. Effect of alcohol on glucose tolerance. Side Effects List Glipizide side effects by likelihood and severity. Glipizide and Metformin HCl Tablets can have other serious side effects. See " What are the possible side effects of Glipizide and Metformin HCl Tablets? Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects.
Several days should elapse between Glipizide titration steps. Patients should be closely monitored for a minimum of 24 to 48 hours since hypoglycemia may recur after apparent clinical recovery. Medicines are sometimes prescribed for purposes other than those listed in a patient information leaflet. Do not use Glucotrol XL for a condition for which it was not prescribed. Do not give Glucotrol XL to other people, even if they have the same symptoms you have. It may harm them. If you have severe hypoglycemia and cannot eat or drink, use a glucagon injection. Januvia and 5mg of Glipizide. generic apetamin-p at target
Do I need a prescription for salmeterol? Use glipizide regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. What happens if I overdose? Glipizide and Metformin HCl Tablets due to hypoglycemic symptoms and 1 required medical intervention due to hypoglycemia. The maximum recommended dose is 20 mg once daily. Q3. Why is it important to control type 2 diabetes? Limited data from controlled pharmacokinetic studies of metformin in healthy elderly subjects suggest that total plasma clearance is decreased, the half-life is prolonged, and Cmax is increased, when compared to healthy young subjects. It is unknown if this medication passes into milk. However, similar drugs pass into milk. Consult your doctor before breast-feeding. Overdosage of sulfonylureas, including glipizide, can produce hypoglycemia. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment. Glucotrol works best if it is taken at the same time each day. Glipizide Tablets, USP are available containing 5 mg or 10 mg of glipizide, USP. Pregnancy may cause or worsen diabetes. Discuss a plan with your doctor for managing your blood sugar while pregnant. Your doctor may change your diabetes treatment during your pregnancy such as diet and medications including insulin. Geil says. "I have no problems with a multivitamin and mineral supplement. Lab tests, including fasting blood glucose, hemoglobin A 1c, and liver function, may be performed while you take Glucotrol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. where can i buy terazosin tablets
If you have any questions or problems, you should talk to your doctor or other healthcare provider about type 2 diabetes as well as Glipizide and Metformin HCl Tablets and its side effects. There is also a leaflet package insert written for health professionals that your pharmacist can let you read. Certain drugs tend to produce and may lead to loss of control. During the insulin withdrawal period, the patient should test urine samples for sugar and at least three times daily. Patients should be instructed to contact the prescriber immediately if these tests are abnormal. In some cases, especially when patient has been receiving greater than 40 units of insulin daily, it may be advisable to consider hospitalization during the transition period. Laboratory Tests: Mild to moderate elevations of ALT, LDH, alkaline phosphatase, BUN and creatinine have been noted. The relationship of these abnormalities to glipizide is uncertain. Find patient medical information for Glipizide Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. xalatan
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Nathaniel Clark, MD, spokesman for the American Diabetes Association. "There's always a need for new therapies and new approaches. GLUCOTROL XL or breastfeed. Some medical conditions may interact with Glucotrol. Use Glucotrol XL extended-release tablets as directed by your doctor. Check the label on the medicine for exact dosing instructions. In initiating treatment for type 2 diabetes, diet should be emphasized as the primary form of treatment. Caloric restriction and weight loss are essential in the obese diabetic patient. Proper dietary management alone may be effective in controlling the blood glucose and symptoms of hyperglycemia. The importance of regular physical activity should also be stressed, and cardiovascular risk factors should be identified and corrective measures taken where possible. Use of Glipizide or other antidiabetic medications must be viewed by both the physician and patient as a treatment in addition to diet and not as a substitution or as a convenient mechanism for avoiding dietary restraint. Furthermore, loss of blood glucose control on diet alone may be transient, thus requiring only short-term administration of Glipizide or other antidiabetic medications. Maintenance or discontinuation of Glipizide or other antidiabetic medications should be based on clinical judgment using regular clinical and laboratory evaluations.
Q13. Where can I get more information about Glipizide and Metformin HCl Tablets? How should I use Serevent Diskus? Glipizide should be given approximately 30 minutes before a meal.
Wardle EN, Richardson GO. Alcohol and glibenclamide. One case of jaundice was reported. The relationship of these abnormalities to GLUCOTROL is uncertain, and they have rarely been associated with clinical symptoms. Store Glucotrol XL extended-release tablets at room temperature, between 59 and 86 degrees F 15 and 30 degrees C. Store away from heat, moisture, light, and humidity. Do not store in the bathroom. Keep Glucotrol XL extended-release tablets out of the reach of children and away from pets.
The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs. Use the medication as soon as you remember, then wait 12 hours before using the medication again. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose? RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions.